- Sirrine, William George, 1870-1951
- Sloan, Harriet E.1
- Smith, D. E. Huger (Daniel Elliott Huger), 1846-19321
- Smith, R. Wilson1
- Snowden, Yates, 1858-19331
- South Carolina Agricultural Convention, 18551
- Southwick, Edmund Bronk, 1848-19381
- Spencer, Charles E.1
- Stephens, E. J.1
- Stoddard, James Alexander, 1876-19491
- Stokes, James William, 1853-19011
- Swearingen, John Eldred, 1875-19571
- Taggart, C. C.1
- Tassie, James, 1735-17991
- Thomas Cooper1
- Thornton, H. R.1
- Trager Manufacturing Company1
- Uhler, Philip Reese, 1835-19131
- Ullman, Samuel, 1840-19241
- University of South Carolina 1