- Millbrook account, n.d.1
- No problems, only challenges : the autobiography of Theodore S. Stern1
- Pinehurst Tea Plantation Visual Materials1
- Porcher Family Papers, 1740-1967 (bulk 19th century)1
- Pringle-Garden Family Papers, 1701-18821
- Quiver1
- Register Mesne Conveyance Collections1
- Richland Library Archives1
- Robert Gilmor Travel Account1
- Robert Heriot Correspondence, 17811
- Robert McNair: In His Own Words1
- Roper Hospital Digital Collections1
- Roswell T. Logan Journal, 1852-18651
- Sabina E. Wells Photographs1
- Samuel Miller apprenticeship indenture, 18051
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Scenes in Charleston, Georgetown, and Flat Rock, Late 19th Century1
- Somebody Had To Do It1
- South Carolina Oyster Industry: A History1