- Cloe T.W. Greene Diaries2
- Edmondston-Alston Family Letters and Paper Materials, 1782-19192
- Heyward and Ferguson Family Papers, 1806-19232
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19202
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library2
- Stereographic Views of South Carolina2
- Allston Family Papers, 1730-19011
- Charleston Museum Collection1
- Charleston and Savannah Railroad Records1
- City Engineers's Plat Book, 1671-19511
- Early History of Columbia College1
- Elizabeth Pringle Diaries1
- Hampstead and Bethany Cemeteries1
- Historic Southern Naturalists1
- John Shaw Billings Scrapbook1
- L.A. Hall Civil War and Reconstruction Eras Stereoscopic Images1
- Letters and Prints from the Campanella Collection of Giuseppe Garibaldi1
- Mayors of Columbia1
- Records of the Church of the Holy Cross, 1788-19421
- Richard Furman and James C. Furman Collection1