- Historic Southern Naturalists5
- Housworth Stereographs Collection1
- Illustrated Newspaper Clippings, 1840-19172
- John McCrady Plats and Deeds Collection1
- John Shaw Billings Scrapbook1
- Midlands Memories
1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19205
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)25
- One Man's Dream - William Plumer Jacobs and Clinton, South Carolina1
- Parish Records12
- Phosphate, Farms, & Family: The Donner Collection2
- Phosphates in South Carolina, 1870-18901
- Primary Sources for K-12, Pilot Project4
- Samuel Lander Papers1
- South Carolina Baptist Church Records79
- South Carolina Historical Society Manuscripts1
- South Caroliniana Library Map Collection3
- South Caroliniana Pamphlet Collection1
- St. Paul's Episcopal Church records, 1819-19711
- The Charleston Earthquake, 18861