- Butler Derrick: In His Own Words7
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library7
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)6
- South Caroliniana Library Map Collection6
- Topographical Maps of South Carolina, 1888 -19756
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19205
- Charleston Earthquake 18864
- South Carolina Baptist Church Records4
- Jewish Heritage Collection Oral Histories3
- South Carolina and the Civil War3
- WPA Federal Writers' Project on African American Life in South Carolina3
- David Wyatt Aiken Papers, 1849-19762
- Eleanor Phelps World Cruise Scrapbook2
- M. Hayes Mizell Papers2
- Postcards of the Midlands2
- Thomas Jones Davies Bible Records2
- Ball Family Papers, 1631-18951
- Books and Pamphlets1
- Cooperative Annual Reports1
- Ethelyn Murray Parker Papers1