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Collection
- Langdon Cheves Papers, 1777-186454
- Ball Family Papers, 1631-189539
- Mary Lamboll Thomas Beach Papers, 1822-189016
- Slave Records in the Discrete Manuscript Collection15
- Adger Family Papers, 1813-193211
- Cranston Family Papers, 1822-195910
- Edmondston-Alston Family Letters and Paper Materials, 1782-19198
- James Simons Papers, 1832-18797
- Bowman Family Papers, 1835-18923
- Eighteenth & Nineteenth Century Correspondence Collection2
- American Revolution Records in the Discrete Manuscript Collection1
- Charleston Bible Society Records, 1815-20101
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)1
- Cora Godfrey Justice Family Papers, 1816-19871
- Glover Family Papers, 1729-ca.19551
- Journal of Samuel Wilson, 18541
- Pinckney Family Papers, 1703-18471
- Porcher Family Papers, 1740-1967 (bulk 19th century)1
- Pringle-Garden Family Papers, 1701-18821
- Robert Heriot Correspondence, 17811