- Rabbi Jacob S. Raisin Papers87
- Stereographic Views of South Carolina86
- Mamie E. Garvin Fields Papers, 1894 - 198785
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192083
- Edmondston-Alston Family Letters and Paper Materials, 1782-191982
- Diaries80
- Medical Society of South Carolina Digital Collections80
- Georgetown County Digital Library77
- Medical University of South Carolina Board of Trustees Collection, 1824-201277
- Francis Peyre Porcher Papers75
- Jewish Heritage Collection Oral Histories74
- Aqui Estamos70
- Waring Historical Library Medical Caricatures68
- South Carolina LGBTQ Oral Histories, Archives, and Outreach64
- Kahal Kadosh Beth Elohim Congregation Records63
- Philip Simmons Collection63
- City Year Books for Charleston, South Carolina, 1880-195162
- Town of Sullivan's Island Historic Meeting Minutes62
- Grimke family papers, 1678-197760
- Cloe T.W. Greene Diaries59