- Adger Family Papers, 1813-193211
- Avery Research Center Oral Histories11
- South Carolina Historical Society Oral Histories11
- South Carolina Library Buildings Collection11
- Anna E. Alston Albums, 1880-192110
- City of Charleston, SC, Report of the City Planning and Zoning Commission, Zone Maps10
- Lazarus and Hirsch Family Papers10
- South Carolina Hospital Postcards10
- William Drayton Rutherford Papers10
- Lewis R. Gibbes Papers, 1800s-1893, 19379
- MUSC College of Pharmacy Class Photos9
- Phillis Wheatley Literary and Social Club Papers9
- Topographical Maps of South Carolina, 1888 -19759
- B. A. Rodrigues Ottolengui Collection8
- Chester County Historical Collection, 1739-19978
- Gabriel Manigault Journal, 1774-17848
- Georgetown County Library Collection8
- James Simons Papers, 1832-18798
- L. Mendel Rivers Papers, 1940-19628
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558