- Ball Family Papers, 1631-18952
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Flagg Family Papers, 1832-19262
- John P. Berry Papers, 1844-18972
- Upstate African American Genealogy2
- Upstate African American Genealogy
2
- Agricultural Experiments and South Mulberry Plantation Journal, 1841-1907 (bulk 1841-1867)1
- Alexander Inglis Papers, 1782-1811 (bulk 1800-1802)1
- American Revolution Records in the Discrete Manuscript Collection1
- Church Session Books Excerpts, 1816-1901.1
- Cora Godfrey Justice Family Papers, 1816-19871
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Edmondston-Alston Family Letters and Paper Materials, 1782-19191
- Ellinor P. Gadsden Family Papers, 1848-19701
- Fraser Family Papers, 1755-18721
- Gabriel Manigault Journal, 1774-17841
- Gaillard Family Papers, 1795-18501
- Glover Family Papers, 1729-ca.19551
- Gourdin Family Collection, 1707-19031
- Isaac Hayne Journal: Register, ca. 1764-17811