- Adger Family Papers, 1813-193211
- Advertisement for Madame Togno's School for Young Ladies, ca. 18551
- Aerial Photos of Columbia, Richland County, South Carolina (Pilot Project)1,985
- Agatha Aimar Simmons Papers, 1903-19621
- Agricultural Experiments and South Mulberry Plantation Journal, 1841-1907 (bulk 1841-1867)1
- Agricultural Society of South Carolina Visual Materials88
- Alan Seeger, Le Poète de la Légion Étrangère1
- Albert Sottile, Jr. Papers125
- Ale boycott records, 18904
- Alexander Glennie Journal, 1831-18591
- Alexander Inglis Papers, 1782-1811 (bulk 1800-1802)2
- Alexander McBeth Store Ledger, 179494
- Alice Ravenel Huger Smith Collection2
- Allen University Digital Collections73
- Alliance for Full Acceptance records16
- Allston Family Papers, 1730-1901247
- American Federation of Musicians Local 502 records, 1911-19143
- American Revolution Records in the Discrete Manuscript Collection28
- Andrews Museum Collection187
- Angelica Singleton Van Buren Collection3