- Rose Hill Plantation Time Books, 18783
- Rose P. Ravenel Family Papers, 1857-ca. 1920.1
- Roslin Plantation Journal, 1813-18151
- Roy S. MacElwee Collection21
- Rural Heritage Lexington County Exhibit photographed by Richard Taylor219
- Russell J. Arnsberger Postcard Collection359
- Russell Maxey Photograph Collection1,940
- S.C. Artifact Documentation Project2
- Samuel Badger Papers, 1767-177314
- Samuel Lander Papers46
- Samuel Miller apprenticeship indenture, 18051
- Samuel Pope, Seaman's Protection Certificate, 18201
- Sanborn Fire Insurance Maps of South Carolina588
- Sandy Island Plantation Journals/Almanacs, 1792-17984
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sarah Campbell Allan, M.D. Papers 1895-19528
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Sargeant Studios133
- School Desegregation in the Southern and Border States53
- Semaphore64