Collection
- Senator Burnet R. Maybank Papers, 1914-1973283
- Septima P. Clark Papers, ca. 1910-ca. 19901,227
- Shadows of the Gullah Geechee20
- Shakespeare First Folio Teaching Resources17
- Sheet Music Collection7
- Sheet music from the Joseph M. Bruccoli Great War Collection1
- Sheet music from the Joseph M. Bruccoli Great War Collection1,206
- Shuford Family Photograph Collection13
- Sidney and Lanny Palmer Collection5
- Singing the Archives4
- Skateboarding's Journey to the Olympics Oral History Collection23
- Slater News76
- Slave Records in the Discrete Manuscript Collection86
- Slavery at South Carolina College, 1801-186558
- Smith and Wells Papers, 1856-1907221
- Solomon Blatt: In His Own Words50
- Somebody Had To Do It9
- South Carolina Aerial Photograph Indexes, 1937-1989355
- South Carolina Artifact Documentation Project2
- South Carolina Baptist Church Records180