- Glenn Drayton journal, 1814-18641
- Golf1
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Gourdin Family Collection, 1707-19031
- Greenville High School Yearbooks1
- Harby Academy Cashbook1
- Hebrew Benevolent Society Papers1
- Henry Laurens Account Book, 1766-17331
- Henry Mouzon Plat Book, 1769-18191
- Henry William Ravenel's Private Journals1
- Heyward Album1
- History of the Charleston Fire Department, 19531
- History of the University of South Carolina School of Medicine – Columbia1
- Housworth Stereographs Collection1
- Huger Family Papers, 1795-18971
- Invoice of rice sales for Anthony Clarkson, 1762 Oct. 301
- Is part of: William Lynch Postcard Collection1
- Isaac Hayne Journal: Register, ca. 1764-17811
- Isabella Sarah Porcher Plantation Prescription Book1
- James N. Cochran Papers, 1838-18871