- Robert F. W. Allston papers, 1817-18681
- Robert Gilmor Travel Account1
- Roper Hospital Digital Collections1
- Rose P. Ravenel Family Papers, 1857-ca. 1920.1
- Roslin Plantation Journal, 1813-18151
- Samuel Miller apprenticeship indenture, 18051
- Samuel Pope, Seaman's Protection Certificate, 18201
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Sheet music from the Joseph M. Bruccoli Great War Collection1
- South Carolina Historical Records Survey Collection 1
- South Carolina Oyster Industry: A History1
- Spartan Legionnaire1
- Spartanburg County In World War II1
- Springfield Plantation Journal,1831 - 18641
- Susan M.L. Wales Journal, 1887-18951
- The Black Whale, by Gabriel E. Manigault1
- The Church Register of the Salem Methodist Episcopal Church, South.1
- The Fundamental Constitutions of Carolina, 16691
- The Little General Yearbook1