- Medical Society of South Carolina Collection1
- Middleton Family Papers, 1736-19291
- Midlands Memories1
- Millbrook account, n.d.1
- Online Exhibits at South Carolina Political Collections1
- Pee Dee District Dental Society Records, 1933-19881
- Pinckney-Means Family Papers, 1701-19831
- Polychronicon Illuminated Manuscript1
- Porcher Family History1
- Porcher Family Papers, 1740-1967 (bulk 19th century)1
- Richard L. Johnson Medical Record Book, 1863-1864, 1867-18831
- Richmond Plantation Journal, 1859-18601
- Robert B. Ariail Collection of Historical Astronomy1
- Robert F. W. Allston papers, 1817-18681
- Robert Gilmor Travel Account1
- Roper Hospital Digital Collections1
- Rose P. Ravenel Family Papers, 1857-ca. 1920.1
- Roslin Plantation Journal, 1813-18151
- Roswell T. Logan Journal, 1852-18651
- Samuel Miller apprenticeship indenture, 18051