- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)1
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Deas Family Papers and Research, 1766-19761
- Ellinor P. Gadsden Family Papers, 1848-19701
- Fraser Family Papers, 1755-18721
- Gabriel Manigault Journal, 1774-17841
- Gaillard Family Papers, 1758-19011
- Gaillard Family Papers, 1795-18501
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Gourdin Family Collection, 1707-19031
- Henry Laurens papers, 1747-18601
- Huger Family Papers, 1795-18971
- Isaac Hayne Journal: Register, ca. 1764-17811
- James N. Cochran Papers, 1838-18871
- John Ravenel Estate Book, 1862-18701
- Journal of Robert Barnwell Plantations, 1838-18591
- Journal of Samuel Wilson, 18541
- Lazarus and Hirsch Family Papers1
- Letter to Harriott Horry, ca. 17801
- Loose Papers of the Summerville Museum and Research Center1