- Mrs. William Timmons Receipt Book, 183138
- Ball Family Papers, 1631-189637
- Bacot Family Papers, 1752-197334
- Diary and Account Book of Rene Ravenel and Henry Ravenel, 1731-186032
- Langdon Cheves III Hunting Notes & Art30
- American Revolution Records in the Discrete Manuscript Collection28
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- Erastus W. Everson Papers, 1837-189322
- Lucas-Porcher Family Papers, 1827-197220
- Mary Lamboll Thomas Beach Papers, 1822-189018
- Cranston Family Papers, 1822-195916
- Pinehurst Tea Plantation Visual Materials16
- Hutson Lee Papers, 1858-186515
- Samuel Badger Papers, 1767-177314
- Adger Family Papers, 1813-193211
- James Simons Papers, 1832-187911
- Letters to Alfred Wardlaw, 1857-186211
- South Carolina Historical Society Oral Histories11
- Voices of the Santee Delta Oral History Project11
- Woodward Manning Papers, 1771-190611