- Micajah Adolphus Clark Journals, 1847-18571
- Midlands Memories1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192019
- Newsletters and Pamphlets1
- Philip Simmons Collection1
- Piedmont Image Collection154
- Postcard Collection of Mullins, South Carolina1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Richard Furman and James C. Furman Collection8
- Russell Maxey Photograph Collection4
- Sanborn Fire Insurance Maps of South Carolina15
- South Carolina Aerial Photograph Indexes, 1937-19896
- South Carolina Baptist Church Records9
- South Carolina Bookmobiles Collection5
- South Carolina Department of Transportation County Road Maps18
- South Carolina Hospital Postcards2
- South Carolina Library Buildings Collection4
- South Carolina Medical Association Oral History Collection1
- South Carolina Pamphlets1
- South Carolina Public Library History, 1930 - 19451