- L.A. Hall Civil War and Reconstruction Eras Stereoscopic Images35
- Langdon Cheves Papers, 1777-18645
- M. Hayes Mizell Papers23
- Mabel Payne Photograph Collection3
- Mamie E. Garvin Fields Papers, 1894 - 19872
- Mary Motte Alston Pringle Receipt Book2
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19202
- Modjeska Simkins Papers, 1909-19921
- New South Newspaper64
- Philip Simmons Collection1
- Phosphate, Farms, & Family: The Donner Collection413
- Pinckney-Means Family Papers, 1701-19831
- Postcards of the Midlands1
- Primary Sources for K-12, Pilot Project7
- Pringle-Garden Family Papers, 1701-18822
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Rabbi Jacob S. Raisin Papers1
- Richard Furman and James C. Furman Collection2
- Rose Hill Plantation Time Books, 18781