- Medical University of South Carolina Board of Trustees Collection, 1824-201277
- Francis Peyre Porcher Papers75
- Aqui Estamos70
- Charleston Museum Collection of Revolutionary War Letters70
- South Carolina LGBTQ Oral Histories, Archives, and Outreach64
- Kahal Kadosh Beth Elohim Congregation Records63
- Philip Simmons Collection63
- City Year Books for Charleston, South Carolina, 1880-195162
- Town of Sullivan's Island Historic Meeting Minutes62
- Grimke family papers, 1678-197761
- Cloe T.W. Greene Diaries59
- Hampstead and Bethany Cemeteries58
- Isaiah Bennett Papers, ca. 1932-200257
- Langdon Cheves Papers, 1777-186456
- Miriam DeCosta Seabrook and Herbert U. Seabrook Papers, 1882-199556
- Thomas Pinckney papers, ca. 1790-ca. 1825.52
- Buildings and Properties, 1841-193749
- College of Charleston Magazines48
- Ansonborough Rehabilitation Project46
- Drayton Family Papers, 1837-186946