- Vincent P. Lannie Collection, 1733-19745
- WPA Federal Writers' Project on African American Life in South Carolina5
- Chesnut Family Papers, 1741-19004
- Cooperative Annual Reports4
- Georgetown County Digital Collection3
- James T. McCain Papers, 1957-19723
- Kenneth Frederick Marsh Photograph Collection3
- Miriam DeCosta Seabrook and Herbert U. Seabrook Papers, 1882-19953
- Russell Maxey Photograph Collection3
- South Carolina Railroad Photograph Collection3
- Chibbaro Stereograph Collection: 186u-19972
- Deas Family Papers and Research, 1766-19762
- Elizabeth W. Allston Pringle Family Papers, 1861-19262
- Hasell Family Papers, 1803 - 18842
- Jewish Heritage Collection Oral Histories2
- Jimmy Price Studios2
- Langdon Cheves Papers, 1777-18642
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19202
- Postcard Collection of Mullins, South Carolina2
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library2