- In Camp And At The Front, WW1 Selections, South Carolina Political Collections1
- Isaiah DeQuincey Newman Papers18
- Jack Keilen Slide Collection17
- James T. McCain Papers, 1957-19725
- John McCrady Plats and Deeds Collection7
- John P. Berry Papers, 1844-18972
- John West: In His Own Words5
- Joseph A. DeLaine Papers1
- Joseph E. Winter Photograph Collection3
- Langdon Cheves Papers, 1777-18641
- Lincoln High School Collection2
- M. Hayes Mizell Papers5
- Mamie E. Garvin Fields Papers, 1894 - 19877
- Mary Motte Alston Pringle Receipt Book1
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)1
- Midlands Memories48
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192013
- Miscellaneous South Carolina Pamphlets1
- Modjeska Simkins Papers, 1909-19921
- Postcards of the Midlands3