- Fraser Family Papers, 1755-18721
- Furman's Legacy of Slavery6
- Gabriel Manigault Journal, 1774-17841
- Gaillard Family Papers, 1795-18501
- Glover Family Papers, 1729-ca.19551
- Gourdin Family Collection, 1707-19031
- Harby, Moise, Levy, Moses, Davis Family Photographs3
- Isaac Hayne Journal: Register, ca. 1764-17811
- James Simons Papers, 1832-187911
- John P. Berry Papers, 1844-18972
- John Ravenel Estate Book, 1862-18701
- Journal of Samuel Wilson, 18541
- Langdon Cheves Papers, 1777-18643
- Laura Benjamin Miller Collection on Judah P. Benjamin1
- Lazarus and Hirsch Family Papers1
- Letters to Alfred Wardlaw, 1857-186210
- Lydia Jane Waring Estate Book, 1840-18471
- Manigault Family Papers, 1685-19711
- Mary Lamboll Thomas Beach Papers, 1822-189010
- Pinckney Family Papers, 1703-18473