- Porcher Family Papers, 1740-1967 (bulk 19th century)1
- Postcard Collection of Mullins, South Carolina44
- Postcards of the Midlands944
- President Robert C. Edwards Papers1,914
- President's Reports to the Board of Trustees8
- Primary Sources for K-12, Pilot Project156
- Pringle-Garden Family Papers, 1701-18824
- Prisma Health19
- Private Collection1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library940
- Program of... the Bishop's Council of the African Methodist Episcopal Church1
- Pungi Lingua1
- Quiver1
- R. Neal Campbell collection69
- R.P. Hamer business letters, 18875
- Rabbi Jacob S. Raisin Papers218
- Ragsdale Family Papers, 1844-ca.192010
- Ravenel Family Papers, 1695-19258
- Records of Charleston fire companies, 1862-18647
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558