- Samuel Badger Papers, 1767-177314
- Samuel Lander Papers46
- Samuel Lord Hyde Photographs137
- Samuel Miller apprenticeship indenture, 18051
- Samuel Pope, Seaman's Protection Certificate, 18201
- Sanborn Fire Insurance Maps of South Carolina588
- Sandy Island Plantation Journals/Almanacs, 1792-17984
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sans Souci14
- Sarah Campbell Allan, M.D. Papers 1895-19528
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Sargeant Studios133
- Scenes in Charleston, Georgetown, and Flat Rock, Late 19th Century12
- Scenes in Charleston, ca. 1940s19
- School Desegregation in the Southern and Border States53
- Schools of Greenviille County4
- Schools of Greenville County139
- Schools of Greenville County
2
- Schools of Greenville County 1
- Semaphore64