Collection
- Senator Burnet R. Maybank Papers, 1914-1973283
- Septima P. Clark Papers, ca. 1910-ca. 19901,227
- Shadows of the Gullah Geechee20
- Shakespeare First Folio Teaching Resources17
- Sheet Music Collection7
- Sheet music from the Joseph M. Bruccoli Great War Collection1
- Sheet music from the Joseph M. Bruccoli Great War Collection1,250
- Shriner's Hospital4
- Shriners Hospital for Children2
- Shuford Family Photograph Collection13
- Sidney and Lanny Palmer Collection5
- Simons & Lapham Architectural Drawings, 1919-195214
- Singing the Archives23
- Skateboarding's Journey to the Olympics Oral History Collection23
- Slater Mill24
- Slater News76
- Slave Records in the Discrete Manuscript Collection87
- Slavery at South Carolina College, 1801-186558
- Slides from Jean Lafitte National Historical Park and Preserve3
- Small-Whaley Family Papers, 1796-19941