Collection
- Sporting Journal of Maxcy Gregg2
- Springfield Plantation Journal,1831 - 18641
- St. Andrew's Society of Charleston Records, 1729-2001118
- St. Francis Health System (Bon Secours)12
- St. Mark United Methodist Church535
- St. Paul's Episcopal Church records, 1819-1971153
- Standard Federal (Columbia S.C.) Photograph Collection219
- State Library Photograph Collection 84
- Steel Heddle13
- Stereographic Views of South Carolina151
- Stereoscopic Photographs146
- Sterling High School Yearbooks1,461
- Stokes Grocery Store Ledger412
- Stoney Family Papers, 1775-19492
- Strom Thurmond Collection, Mss 1001,156
- Sullivan's Island Oral History Collection15
- Summerville Museum and Research Center Pamphlet Collection9
- Survey of Fauna3
- Survey of National Parks19
- Susan M.L. Wales Journal, 1887-18951