- Marlboro County Public Library Historic Documents1
- Martha Elizabeth Cunningham Monteith Collection 1
- Materials towards a history of the Baptists in the provinces of Maryland, Virginia, North Carolina, South Carolina, Georgia1
- Mathurin Guerin Gibbs Plantation Register, 1824-18751
- Matthew J. & Arlyn Bruccoli Collection of F. Scott Fitzgerald1
- McKinnon Pastoral Record Book1
- McLeod Plantation Cemetery Collection1
- Medical College Expansion Program Lantern Slides,1
- Medical Society of South Carolina Collection1
- Middleton Family Art Work, 1803-18671
- Middleton Family Papers, 1736-19291
- Millbrook account, n.d.1
- Mulberry Castle: Land of My Dreams1
- Natural Histories of Irvin Department of Rare Books1
- New insights in the American Civil Rights Movement: South Carolina Council on Human Relations records1
- No problems, only challenges : the autobiography of Theodore S. Stern1
- Opus postillarum et sermonum de termpore1
- Ordinatio1
- Pee Dee District Dental Society Records, 1933-19881
- Pharsalia1