- Rose P. Ravenel Family Papers, 1857-ca. 1920.1
- Roslin Plantation Journal, 1813-18151
- Roswell T. Logan Journal, 1852-18651
- Sabina E. Wells Photographs1
- Samuel Miller apprenticeship indenture, 18051
- Samuel Pope, Seaman's Protection Certificate, 18201
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Schools of Greenville County 1
- Sheet music from the Joseph M. Bruccoli Great War Collection1
- Small-Whaley Family Papers, 1796-19941
- South Carolina Historical Records Survey Collection 1
- South Carolina Oyster Industry: A History1
- South Caroliniana Library Map Collection
1
- Spartan Legionnaire1
- Spartanburg County In World War II1
- Speculum Beatae Mariae Virginis1
- Springfield Plantation Journal,1831 - 18641
- Susan M.L. Wales Journal, 1887-18951
- Textiles - Miscellaneous Textiles
1