- Santee Avenue, Columbia, S.C.6
- Santee River in Berkeley County (S.C.)1
- Sarasota (Fla.)8
- Savannah (Ga.)5
- Schiele Museum of Natural History, Gastonia, North Carolina1
- Schiele Museum of Natural History, Gastonia, South Carolina1
- Schilletter Dining Hall10
- Scotia (S.C.)7
- Scranton (S.C.)8
- Sellers (S.C.)8
- Seminole Road, Columbia, S.C.1
- Senate Street, Columbia, S.C.14
- Seneca (S.C.)6
- Sesquicentennial State Park (S.C.)3
- Shanghai, China1
- Sharon (S.C.)8
- Sharpe Road, Columbia, S.C.1
- Shartlesville (Penn.)1
- Shaw Air Force Base (S.C.)7
- Shelton (S.C.)15