- Southern States1
- Sparkman, John, 1899-19851
- Spartanburg Downtown Memorial Airport1
- Special days1
- Special weeks1
- Sputnik satellites1
- States Rights League1
- Status of forces agreements1
- Stennis, John C. (John Cornelius), 1901-19951
- Summerall, Charles Pelot, 1867-19551
- Summerville School District #2 (Dorchester County, S.C.)1
- Sumter National Forest (S.C.)1
- Symington, Stuart, 1901-19881
- Taiwan1
- Taiwan Strait1
- Tariff1
- Television broadcasting1
- Tilghman Beach Pier Corporation1
- Timmerman, George Bell, 1912-19941
- Transportation, Military1