- Rock Hill (Spartanburg County, S.C.)1
- Roebuck (Spartanburg County, S.C.)1
- Roebuck Presbyterian (Spartanburg County, S.C.)1
- Roman Catholic -- South Carolina -- Spartanburg County1
- Rosemond, J.1
- Ross, E. G.1
- Salem Methodist (Spartanburg County, S.C.)1
- Salvation Army -- South Carolina -- Spartanburg County1
- Sardis (Spartanburg County, S.C.)1
- Saxon Avenue Free Will Baptist (Spartanburg County, S.C.)1
- Saxon Baptist (Spartanburg County, S.C.)1
- Saxon Church of God (Saxon Mill Village, S.C.)1
- Saxon Methodist (Spartanburg County, S.C.)1
- Sayer, J. M.1
- Scarlatina1
- Scarlet Fever1
- Scruggs, D.1
- Second Baptist (Spartanburg County, S.C.)1
- Second Presbyterian (Spartanburg County, S.C.)1
- Shaffer1