- Sloan, John T., 1811-1895--Dwellings1
- Smith, Cora Lee1
- Smith, Dean C., 1899-19875
- Smith, James Delaney2
- Smith, John1
- Smith, Lillie Mae2
- Smith, Margaret Ann5
- Smith, Rosena1
- Snakes1
- Snow4
- Snowmen2
- Soldiers51
- South Carolina American Revolution Bicentennial Commission1
- South Carolina Gay and Lesbian Pride Movement38
- South Carolina Governor's Mansion (Columbia, S.C.)1
- South Carolina Penitentiary1
- South Carolina State College6
- South Carolina State Hospital1
- South Carolina State House (Columbia, S.C.)59
- Southern Cotton Oil Company5