- Davis, Braxton Bragg, 1862-19353
- Davis, Braxton Middleton, 1899-19874
- DeSoto Hotel (Columbia, S.C.)2
- Delta Sigma Theta Sorority. Richland County Alumnae Chapter1
- Department stores1
- Derrick, Martha Kesler, 1866-19501
- Dial, Caroline Dick McKissick Belser, 1900-19941
- Dirksen, Everett McKinley1
- Dodge automobile1
- Dogs8
- Douglas, Joseph William2
- Dreher High School (Columbia, S.C.)4
- Dreher, Ernest1
- Drugstores3
- Dwellings76
- Earlewood (Columbia, S.C.)5
- Ebenezer Lutheran Church (Columbia, S.C.)16
- Edisto River (S.C.)1
- Elementary schools1
- Episcopal churches3