- Darrin, Diana1
- Davidson, John, 1941-5
- Davis, Bette, 1908-19891
- Davis, Jim, 1909-19816
- Davis, Kristin, 1966-1
- Dean, Dizzy, 1910-19743
- Debutantes2
- Delorme, Harold M., 1901-19701
- Delta Air Lines2
- Democratic Party (S.C.)52
- Demonstrations366
- Dennis, Rembert C. (Rembert Coney), 1915-19922
- Dent, Harry S. , 1930-20074
- Dentsville Elementary School (Columbia, S.C.)1
- Dentsville High School (Columbia, S.C.)4
- Department stores99
- Derrick, Butler Carson, Jr., 1936-20142
- Devine, Andy, 1905-19772
- Dial, Caroline Dick McKissick Belser, 1900-19942
- Dickey, James7